ELLANSÉ^® – M
9 months post injection

Haematoxylin & Eosin staining shows:

• Microspheres still round and intact during bioresorption process
• Collagen fibers are stained red

ELLANSÉ^® – M
9 months post injection⁹

Picro Sirius Red (PSR), Polarized light shows :

• Red (arrows): collagen type I
• Green (arrowheads): collagen type III
• Confirmation of neocollagenesis

ELLANSÉ^® – M
21 months post injection

Picro Sirius Staining, Polarized light shows :

• Red colour confirming predominant presence of collagen type I
• Type I collagen confirms stable environment and long-term efficacy

Ellansé^® – M
13 months after ELLANSÉ^®

PCL microspheres were surrounded with collagen deposition and a mild fibroblastic and histiocytic tissue response.

Stainings were Haematoxylin & Eosin (A and B) and Martin-s Trichrome (C and D)